How to Increase Orexin Orexin, also known as hypocretin, is a hormone that controls your sleep patterns and might impact your metabolism and ability to lose weight. If your body doesn't produce enough orexin, you can adjust your diet by eating less sugar and carbs, for instance. Your doctor may recommend supplements or medication as well. You can also take care of your body by exercising and losing weight to increase your orexin levels naturally. snake game